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ANTXR1 Intronic Variants Are Associated with Fetal Hemoglobin in the Arab-Indian Haplotype of Sickle Cell Disease.

Acta haematologica - 1 Jan 2018

Al-Ali Zhara A, Fallatah Rana K, Aljaffer Esra A, Albukhari Eman R, Sadek Al-Ali Neriman, Al-Ghannam Ziyad T, Sayeb Al-Atrash Reem, Alsuliman Ahmed, Vatte Chittibabu

Abstract excerpt

Disease severity of sickle cell anemia is highly variable, and it is commonly accepted that fetal hemoglobin (HbF) levels play a major role as an ameliorating factor. Investigation of genetic variants have identified several genes to be the principal influencers of HbF regulation. Here, we further elucidated the association of rs4527238 and rs35685045 of ANTXR1 genes in the context of HbF level variance in sickle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30114697
DOI: 10.1159/000491688

Genes

ANTXR1

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