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Article

The Genetic and Clinical Significance of Fetal Hemoglobin Expression in Sickle Cell Disease.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre - 1 Jan 2021

Adekile Adekunle

Abstract excerpt

Sickle cell disease (SCD) is phenotypically heterogeneous. One major genetic modifying factor is the patient's fetal hemoglobin (HbF) level. The latter is determined by the patient's β-globin gene cluster haplotype and cis- and trans-acting single nucleotide polymorphisms (SNPs) at other distant quantitative trait loci (QTL). The Arab/India haplotype is associated with persistently high HbF levels and also a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32892201
DOI: 10.1159/000511342
PMCID: PMC8280415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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