Hb F Levels in Indian Sickle Cell Patients and Association with the HBB Locus Variant rs10128556 (C>T), and the HBG XmnI (Arab-Indian) Variant.

doi:10.1080/03630269.2017.1414059

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Hb F Levels in Indian Sickle Cell Patients and Association with the HBB Locus Variant rs10128556 (C>T), and the HBG XmnI (Arab-Indian) Variant.

Hemoglobin - 1 Jan 2000

Bhanushali Aparna A, Himani Kumari, Patra Pradeep K, Das Bibhu R

Abstract excerpt

The prevalence of sickle cell disease in India is very high. Hb F is one of the most powerful modulators of disease severity in sickle cell disease patients. It was traditionally thought that the disease is milder in Indian sickle cell disease patients predominantly due to the Arab-Indian haplotype characterized by the HBG XmnI [rs7482144 (G>A)] variant, which is associated with increased Hb F levels. In the...

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PMID: 29313433
DOI: 10.1080/03630269.2017.1414059

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