Article
BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia.
Blood cells, molecules & diseases - 1 Mar 2015
Sebastiani P, Farrell J J, Alsultan A, Wang S, Edward H L, Shappell H, Bae H, Milton J N, Baldwin C T, Al-Rubaish A M, Naserullah Z, Al-Muhanna F, Alsuliman A, Patra P K, Farrer L A, Ngo D, Vathipadiekal V, Chui D H K, Al-Ali A K, Steinberg M H
Abstract excerpt
BACKGROUND: Fetal hemoglobin (HbF) levels in sickle cell anemia patients vary. We genotyped polymorphisms in the erythroid-specific enhancer of BCL11A to see if they might account for the very high HbF associated with the Arab-Indian (AI) haplotype and Benin haplotype of sickle cell anemia. METHODS AND RESULTS: Six BCL112A enhancer SNPs and their haplotypes were studied in Saudi Arabs from the Eastern Province...
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