Article
A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia.
American journal of hematology - 1 Nov 2016
Vathipadiekal Vinod, Farrell John J, Wang Shuai, Edward Heather L, Shappell Heather, Al-Rubaish A M, Al-Muhanna Fahad, Naserullah Z, Alsuliman A, Qutub Hatem Othman, Simkin Irene, Farrer Lindsay A, Jiang Zhihua, Luo Hong-Yuan, Huang Shengwen, Mostoslavsky Gustavo, Murphy George J, Patra Pradeep K, Chui David H K, Alsultan Abdulrahman, Al-Ali Amein K, Sebastiani Paola, Steinberg Martin H
Abstract excerpt
Fetal hemoglobin (HbF) levels are higher in the Arab-Indian (AI) β-globin gene haplotype of sickle cell anemia compared with African-origin haplotypes. To study genetic elements that effect HbF expression in the AI haplotype we completed whole genome sequencing in 14 Saudi AI haplotype sickle hemoglobin homozygotes-seven selected for low HbF (8.2% ± 1.3%) and seven selected for high HbF (23.5% ± 2.6%). An...
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