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Article

Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype.

Blood cells, molecules & diseases - 1 Jun 2013

Ngo Duyen, Bae Harold, Steinberg Martin H, Sebastiani Paola, Solovieff Nadia, Baldwin Clinton T, Melista Efthymia, Safaya Surinder, Farrer Lindsay A, Al-Suliman Ahmed M, Albuali Waleed H, Al Bagshi Muneer H, Naserullah Zaki, Akinsheye Idowu, Gallagher Patrick, Luo Hong-yuan, Chui David H K, Farrell John J, Al-Ali Amein K, Alsultan Abdulrahman

Abstract excerpt

Sickle cell anemia is common in the Middle East and India where the HbS gene is sometimes associated with the Arab-Indian (AI) β-globin gene (HBB) cluster haplotype. In this haplotype of sickle cell anemia, fetal hemoglobin (HbF) levels are 3-4 fold higher than those found in patients with HbS ha...

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Identifiers

PMID: 23465615
DOI: 10.1016/j.bcmd.2012.12.005
PMCID: PMC3647015

Genes

HBB
KLF1
MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23465615-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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