Article
Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype.
Blood cells, molecules & diseases - 1 Jun 2013
Ngo Duyen, Bae Harold, Steinberg Martin H, Sebastiani Paola, Solovieff Nadia, Baldwin Clinton T, Melista Efthymia, Safaya Surinder, Farrer Lindsay A, Al-Suliman Ahmed M, Albuali Waleed H, Al Bagshi Muneer H, Naserullah Zaki, Akinsheye Idowu, Gallagher Patrick, Luo Hong-yuan, Chui David H K, Farrell John J, Al-Ali Amein K, Alsultan Abdulrahman
Abstract excerpt
Sickle cell anemia is common in the Middle East and India where the HbS gene is sometimes associated with the Arab-Indian (AI) β-globin gene (HBB) cluster haplotype. In this haplotype of sickle cell anemia, fetal hemoglobin (HbF) levels are 3-4 fold higher than those found in patients with HbS haplotypes of African origin. Little is known about the genetic elements that modulate HbF in AI haplotype patients. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.