Article
Our changing view of the genomic landscape of cancer.
The Journal of pathology - 1 Jan 2010
Bell Daphne W
Abstract excerpt
Sporadic tumours, which account for the majority of all human cancers, arise from the acquisition of somatic, genetic and epigenetic alterations leading to changes in gene sequence, structure, copy number and expression. Within the last decade, the availability of a complete sequence-based map of the human genome, coupled with significant technological advances, has revolutionized the search for somatic...
Topics
- Cell Transformation, Neoplastic
- Gene Expression Profiling
- Genes, Neoplasm
- Genome, Human
- Genomics
- Humans
- Mutation
- Neoplasms
- Signal Transduction