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Decoding complex patterns of genomic rearrangement in hepatocellular carcinoma

21 Jan 2014

Abstract excerpt

Elucidating the molecular basis of hepatocellular carcinoma (HCC) is crucial to developing targeted diagnostics and therapies for this deadly disease. The landscape of somatic genomic rearrangements (GRs), which can lead to oncogenic gene fusions, remains poorly characterized in HCC. We have predicted 4314 GRs including large-scale insertions, deletions, inversions and translocations based on the whole-genome...

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PMID: 24462510
DOI: 10.1016/j.ygeno.2014.01.003

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