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Article

Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain.

Structure (London, England : 1993) - 7 Aug 2018

Emptage Ryan P, Lemmon Mark A, Ferguson Kathryn M, Marmorstein Ronen

Abstract excerpt

The kinase associated-1 (KA1) domain is found at the C-terminus of multiple Ser/Thr protein kinases from yeast to humans, and has been assigned autoinhibitory, membrane-binding, and substrate-targeting roles. Here, we report the crystal structure of the MARK1 kinase/UBA domain bound to its autoinhibitory KA1 domain, revealing an unexpected interface at the αD helix and contacts with both the N- and C-lobes of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Conformation, alpha-Helical

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Source

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Identifiers

PMID: 30099988
DOI: 10.1016/j.str.2018.05.008
PMCID: PMC6092042

Genes

MARK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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