Article
Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.
Structure (London, England : 1993) - 1 Feb 2006
Panneerselvam Saravanan, Marx Alexander, Mandelkow Eva-Maria, Mandelkow Eckhard
Abstract excerpt
The Ser/Thr kinase MARK2 phosphorylates tau protein at sites that cause detachment from microtubules in Alzheimer neurofibrillary degeneration. Homologs of MARK2 include Par-1 in C. elegans and Drosophila, which generates embryonic polarity. We report the X-ray structure of the catalytic and ubiquitin-associated domains (UBA) of human MARK2. The activity was altered by mutations in the ATP binding site and/or...
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