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Article

Distinct structural mechanisms determine substrate affinity and kinase activity of protein kinase Cα.

The Journal of biological chemistry - 29 Sept 2017

Lee Sangbae, Devamani Titu, Song Hyun Deok, Sandhu Manbir, Larsen Adrien, Sommese Ruth, Jain Abhinandan, Vaidehi Nagarajan, Sivaramakrishnan Sivaraj

Abstract excerpt

Protein kinase Cα (PKCα) belongs to the family of AGC kinases that phosphorylate multiple peptide substrates. Although the consensus sequence motif has been identified and used to explain substrate specificity for PKCα, it does not inform the structural basis of substrate-binding and kinase activity for diverse substrates phosphorylated by this kinase. The transient, dynamic, and unstructured nature of this...

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Identifiers

PMID: 28821615
DOI: 10.1074/jbc.M117.804781
PMCID: PMC5625059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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