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Article

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase

3 Jul 2019

Abstract excerpt

BTB-Kelch proteins form the largest subfamily of Cullin-RING E3 ligases, yet their substrate complexes are mapped and structurally characterized only for KEAP1 and KLHL3. KLHL20 is a related CUL3-dependent ubiquitin ligase linked to autophagy, cancer, and Alzheimer's disease that promotes the ubiquitination and degradation of substrates including DAPK1, PML, and ULK1. We identified an "LPDLV"-containing motif in...

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PMID: 31279627
DOI: 10.1016/j.str.2019.06.005

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