Article
A cis-eQTL of HLA-DPB1 Affects Susceptibility to Type 1 Autoimmune Hepatitis.
Scientific reports - 9 Aug 2018
Yamazaki Tomoo, Umemura Takeji, Joshita Satoru, Yoshizawa Kaname, Tanaka Eiji, Ota Masao
Abstract excerpt
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease characterized by an autoimmune reaction to hepatocytes. A single nucleotide polymorphism in the 3' untranslated region of HLA-DPB1, rs9277534, is associated with HLA-DPB1 expression. rs9277534 has been linked to hepatitis B virus recovery/persistence and the risk of graft-versus-host disease with HLA-DPB1 mismatching transplantation of...
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