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Article

A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.

Nature genetics - 1 May 2009

Kamatani Yoichiro, Wattanapokayakit Sukanya, Ochi Hidenori, Kawaguchi Takahisa, Takahashi Atsushi, Hosono Naoya, Kubo Michiaki, Tsunoda Tatsuhiko, Kamatani Naoyuki, Kumada Hiromitsu, Puseenam Aekkachai, Sura Thanyachai, Daigo Yataro, Chayama Kazuaki, Chantratita Wasun, Nakamura Yusuke, Matsuda Koichi

Abstract excerpt

Chronic hepatitis B is a serious infectious liver disease that often progresses to liver cirrhosis and hepatocellular carcinoma; however, clinical outcomes after viral exposure vary enormously among individuals. Through a two-stage genome-wide association study using 786 Japanese chronic hepatitis B cases and 2,201 controls, we identified a significant association of chronic hepatitis B with 11 SNPs in a region...

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PMID: 19349983
DOI: 10.1038/ng.348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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