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Article

CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study.

BMC medical genetics - 20 Jan 2010

Castellucci Léa, Jamieson Sarra E, Miller E Nancy, Menezes Eliane, Oliveira Joyce, Magalhães Andrea, Guimarães Luiz Henrique, Lessa Marcus, de Jesus Amélia Ribeiro, Carvalho Edgar M, Blackwell Jenefer M

Abstract excerpt

BACKGROUND: L. braziliensis causes cutaneous (CL) and mucosal (ML) leishmaniasis. Wound healing neutrophil (PMN) and macrophage responses made following the bite of the vector sand fly contribute to disease progression in mice. To look at the interplay between PMN and macrophages in disease progression in humans we asked whether polymorphisms at genes that regulate their infiltration or function are associated...

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Source

Open in PubMed Open full text

Identifiers

PMID: 20089160
DOI: 10.1186/1471-2350-11-10
PMCID: PMC2823618

Genes

CXCR1
CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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