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Article

Knops blood group polymorphism and susceptibility to Mycobacterium tuberculosis infection.

Transfusion - 1 Nov 2011

Noumsi Ghislain T, Tounkara Anatole, Diallo Hama, Billingsley Katrina, Moulds John J, Moulds Joann M

Abstract excerpt

BACKGROUND: Complement receptor 1 (CR1) protein carries the Knops blood group antigens and is the receptor for the major ligand involved in Mycobacterium tuberculosis (Mtb) adhesion to macrophages. Erythrocyte CR1 binds immune complexes (ICs) formed during Mtb invasion, facilitating their clearance by the host immune system. The occurrence of specific Knops blood group genotypes among African populations was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21569042
DOI: 10.1111/j.1537-2995.2011.03161.x

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