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Article

MRGPRX 2 is negatively targeted by SCF and IL ‐4 to diminish pseudo‐allergic stimulation of skin mast cells in culture

9 Aug 2018

Abstract excerpt

MRGPRX2 was recently uncovered as the "missing link" in clinically relevant mast cell (MC) activation explaining previously puzzling phenomena. It is the receptor for various endogenous ligands and exogenous compounds alike, whose binding evokes rapid degranulation much like allergen-mediated exocytosis. While the perceivable outcomes are similar, the two activation routes differ regarding mechanism and...

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Share to Allergic Rhinitis and Sensitization
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PMID: 30091263
DOI: 10.1111/exd.13762

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