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Article

Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease.

The Journal of allergy and clinical immunology - 1 Aug 2021

Roy Saptarshi, Chompunud Na Ayudhya Chalatip, Thapaliya Monica, Deepak Vishwa, Ali Hydar

Abstract excerpt

Cutaneous mast cells (MCs) express Mas-related G protein-coupled receptor-X2 (MRGPRX2; mouse ortholog MrgprB2), which is activated by an ever-increasing number of cationic ligands. Antimicrobial host defense peptides (HDPs) generated by keratinocytes contribute to host defense likely by 2 mechanisms, one involving direct killing of microbes and the other via MC activation through MRGPRX2. However, its...

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Identifiers

PMID: 33957166
DOI: 10.1016/j.jaci.2021.03.049
PMCID: PMC8355064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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