Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Multifaceted Mas-Related G Protein-Coupled Receptor Member X2 in Allergic Diseases and Beyond

23 Apr 2021

Abstract excerpt

Recent research on mast cell biology has turned its focus on MRGPRX2, a new member of the Mas-related G protein-coupled subfamily of receptors (Mrgprs), originally described in nociceptive neurons of the dorsal root ganglia. MRGPRX2, a member of this group, is present not only in neurons but also in mast cells (MCs), specifically, and potentially in other cells of the immune system, such as basophils and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to Mast cells and histamine
Share to Receptor Mechanisms and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33922606
DOI: 10.3390/ijms22094421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Multifaceted Mas-Related G Protein-Coupled Receptor Member X2 in Allergic Diseases and BeyondPMID 33922606Read ↗

Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease.Semantic proximity Read ↗

Structural determinants of ligand response specificity in the mast cell activating GPCR, MRGPRX2.Semantic proximity Read ↗

Revisiting the role of MRGPRX2 on hypersensitivity reactions to neuromuscular blocking drugs.Semantic proximity Read ↗

Naturally Occurring Missense MRGPRX2 Variants Display Loss of Function Phenotype for Mast Cell Degranulation in Response to Substance P, Hemokinin-1, Human β-Defensin-3, and Icatibant.Semantic proximity Read ↗

MRGPRX2 facilitates IgE-mediated systemic anaphylaxis in a newly established knock-in mouse modelSemantic proximity Read ↗

G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: Roles of Mas-related genes MrgX1 and MrgX2Semantic proximity Read ↗

The role of the neutrophil receptor Mrgpra2 in the formation of itch in atopic dermatitisSemantic proximity Read ↗

Decoding the neuroimmune axis in the atopic march: mechanisms and implicationsSemantic proximity Read ↗

MRGPRX 2 is negatively targeted by SCF and IL ‐4 to diminish pseudo‐allergic stimulation of skin mast cells in cultureSemantic proximity Read ↗

PMX-53 as a Dual CD88 Antagonist and an Agonist for Mas-Related Gene 2 (MrgX2) in Human Mast CellsSemantic proximity Read ↗

Mast Cells as Key Players in Allergy and InflammationSemantic proximity Read ↗

Molecular signature of pruriceptive MrgprA3 <sup>+</sup> neuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.