Article
Culturing cells with mast cell phenotype and function: Comparison of peripheral blood and bone marrow as a source.
Journal of immunological methods - 1 Aug 2021
Elst Jessy, Ebo Didier G, Faber Margaretha A, Van Gasse Athina L, Decuyper Ine I, van der Poorten Marie-Line M, Bridts Chris H, De Puysseleyr Leander P, Mertens Christel, Hagendorens Margo M, De Clerck Luc S, Walschot Mark, Verlinden Anke, Berger Daniela, Valent Peter, Sabato Vito
Abstract excerpt
BACKGROUND: Studies on the mechanisms that govern mast cell (MC) functions are hindered by the difficulties in isolating sufficient numbers of these tissue-resident cells. Therefore, many research groups use cultured human MCs obtained out of progenitor cells. However, these culture methods significantly differ regarding primary source material, culture durations and conditions. Consequently, the finally obtained...
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