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Article

RBL cells as models for in vitro studies of mast cells and basophils

12 Feb 2018

Abstract excerpt

Since their establishment in 1981, RBL-2H3 cells have been widely used as a mast cell (MC) model. Their ability to be easily grown in culture in large amounts, their responsiveness to FcεRI-mediated triggers and the fact that they can be genetically manipulated, have provided advantages over primary MCs, in particular for molecular studies relying on genetic screening. Furthermore, the ability to generate clones...

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
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PMID: 29431208
DOI: 10.1111/imr.12628

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