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Article

Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of cdk4-C/EBPα-p300 Axis.

Cell reports - 7 Aug 2018

Nguyen Phuong, Valanejad Leila, Cast Ashley, Wright Mary, Garcia Jose M, El-Serag Hashem B, Karns Rebekah, Timchenko Nikolai A

Abstract excerpt

The aging liver is affected by several disorders, including steatosis, that can lead to a decline of liver functions. Here, we present evidence that the cdk4-C/EBPα-p300 axis is a critical regulator of age-associated disorders, including steatosis. We found that patients with non-alcoholic fatty liver disease (NAFLD) have increased levels of cdk4 and that cdk4-resistant C/EBPα-S193A mice do not develop hepatic...

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Identifiers

PMID: 30089269
DOI: 10.1016/j.celrep.2018.07.014
PMCID: PMC8209958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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