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Article

Epigenetic changes play critical role in age-associated dysfunctions of the liver.

Aging cell - 1 Oct 2010

Jin Jingling, Wang Guo-Li, Iakova Polina, Shi Xiurong, Haefliger Simon, Finegold Milton, Timchenko Nikolai A

Abstract excerpt

CCAAT/Enhancer Binding Proteins family proteins are important regulators of liver functions. Here, we show the critical role of C/EBPα-mediated chromatin remodeling in the age-associated dysfunctions of the liver and in the maintenance of physiological homeostasis. Because ph-S193 isoform of C/EBPα is increased in livers of old mice, we have generated C/EBPα-S193D knockin mice, which mimic the ph-S193 isoform of...

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Source

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Identifiers

PMID: 20698834
DOI: 10.1111/j.1474-9726.2010.00617.x
PMCID: PMC3046424

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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