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Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

2 Oct 2019

Abstract excerpt

Aging is characterized by the progressive loss of physiological function in all organisms. Remarkably, the aging process can be modulated by environmental modifications, including diet and small molecules. The natural compound nordihydroguaiaretic acid (NDGA) robustly increases lifespan in flies and mice, but its mechanism of action remains unclear. Here, we report that NDGA is an inhibitor of the epigenetic...

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Share to Autophagy in Disease and Therapy
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PMID: 31602311
DOI: 10.1038/s41514-019-0037-7

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