Article
miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions.
American journal of physiology. Lung cellular and molecular physiology - 1 Mar 2017
Cui Huachun, Ge Jing, Xie Na, Banerjee Sami, Zhou Yong, Liu Rui-Ming, Thannickal Victor J, Liu Gang
Abstract excerpt
Idiopathic pulmonary fibrosis is a well-known age-related disease. However, much less recognized has been the aging associated pathogenesis of this disorder. As we and others previously showed that dysregulation of micro-RNAs (miRNAs) was an important mechanism involved in pulmonary fibrosis, the role of these molecules in this pathology in the aged population has not been investigated (Cushing L, Kuang PP, Qian...
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