Article
Comparative analysis of targeted next-generation sequencing panels for the detection of gene mutations in chronic lymphocytic leukemia: an ERIC multi-center study.
Haematologica - 1 Mar 2021
Sutton Lesley-Ann, Ljungström Viktor, Enjuanes Anna, Cortese Diego, Skaftason Aron, Tausch Eugen, Stano Kozubik Katerina, Nadeu Ferran, Armand Marine, Malcikova Jikta, Pandzic Tatjana, Forster Jade, Davis Zadie, Oscier David, Rossi Davide, Ghia Paolo, Strefford Jonathan C, Pospisilova Sarka, Stilgenbauer Stephan, Davi Frederic, Campo Elias, Stamatopoulos Kostas, Rosenquist Richard, On Behalf Of The European Research Initiative On Cll Eric
Abstract excerpt
Next-generation sequencing (NGS) has transitioned from research to clinical routine, yet the comparability of different technologies for mutation profiling remains an open question. We performed a European multicenter (n=6) evaluation of three amplicon-based NGS assays targeting 11 genes recurrently mutated in chronic lymphocytic leukemia. Each assay was assessed by two centers using 48 pre-characterized...
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