Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis in BCR-ABL1 positive leukemia by deep sequencing based on nanopore MinION technology.

Experimental and molecular pathology - 1 Aug 2017

Minervini Crescenzio F, Cumbo Cosimo, Orsini Paola, Anelli Luisa, Zagaria Antonella, Impera Luciana, Coccaro Nicoletta, Brunetti Claudia, Minervini Angela, Casieri Paola, Tota Giuseppina, Russo Rossi Antonella, Specchia Giorgina, Albano Francesco

Abstract excerpt

We report a third-generation sequencing assay on nanopore technology (MinION) for detecting BCR-ABL1 KD mutations and compare the results to a Sanger sequencing(SS)-based test in 24 Philadelphia-positive (Ph+) leukemia cases. Our data indicates that MinION is markedly superior to SS in terms of sensitivity, costs and timesaving, and has the added advantage of determining the clonal configuration of multiple...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis
Share to Fusion Proteins, bcr-abl

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ABL1 gene

Share to High-Throughput Nucleotide Sequencing

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Mutation

Share to Nanopores

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 28663031
DOI: 10.1016/j.yexmp.2017.06.007

Genes

ABL1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis in BCR-ABL1 positive leukemia by deep sequencing based on nanopore MinION technology.PMID 28663031Read ↗

Design and MinION testing of a nanopore targeted gene sequencing panel for chronic lymphocytic leukemiaSemantic proximity Read ↗

TP53 gene mutation analysis in chronic lymphocytic leukemia by nanopore MinION sequencing.Semantic proximity Read ↗

Ultrarapid Targeted Nanopore Sequencing for Fusion Detection of LeukemiasSemantic proximity Read ↗

Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA.Semantic proximity Read ↗

Nanopore Targeted Sequencing for Rapid Gene Mutations Detection in Acute Myeloid Leukemia.Semantic proximity Read ↗

Next-generation sequencing for BCR-ABL1 kinase domain mutations in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: A position paper.Semantic proximity Read ↗

Next-generation sequencing for BCR-ABL1 kinase domain mutation testing in patients with chronic myeloid leukemia: a position paper.Semantic proximity Read ↗

Detection of Kinase Domain Mutations in BCR-ABL1 Leukemia by Ultra-deep Sequencing of Genomic DNASemantic proximity Read ↗

The diagnostic chronic lymphocytic leukaemia genome by nanopore sequencingSemantic proximity Read ↗

Genomic BCR-ABL1 breakpoint characterization by a multi-strategy approach for “personalized monitoring” of residual disease in chronic myeloid leukemia patientsSemantic proximity Read ↗

Partial Anchored Capture and Long-Read Sequencing (PACLseq) Enable a Stand-alone Diagnostic Method for Ph-like Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Rapid multiplex small DNA sequencing on the MinION nanopore sequencing platformSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.