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Article

TP53 gene mutation analysis in chronic lymphocytic leukemia by nanopore MinION sequencing.

Diagnostic pathology - 10 Oct 2016

Minervini Crescenzio Francesco, Cumbo Cosimo, Orsini Paola, Brunetti Claudia, Anelli Luisa, Zagaria Antonella, Minervini Angela, Casieri Paola, Coccaro Nicoletta, Tota Giuseppina, Impera Luciana, Giordano Annamaria, Specchia Giorgina, Albano Francesco

Abstract excerpt

BACKGROUND: The assessment of TP53 mutational status is becoming a routine clinical practice for chronic lymphocytic leukemia patients (CLL). A broad spectrum of molecular techniques has been employed so far, including both direct Sanger sequencing and next generation sequencing. Oxford Nanopore Technologies recently released the MinION an USB-interfaced sequencer. In this paper we report our experience, with the...

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Identifiers

PMID: 27724982
DOI: 10.1186/s13000-016-0550-y
PMCID: PMC5057401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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