Article
Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development.
Glycoconjugate journal - 1 Jan 2000
Wilson Valerie A, Gallagher John T, Merry Catherine L R
Abstract excerpt
Heparan sulphate 2-O-sulphotransferase (Hs2st) acts at an intermediate stage in the pathway of biosynthesis of heparan sulphate (HS), catalysing the transfer of sulphate from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to the C2-position of selected hexuronic acid residues within the maturing HS chain. It is well established that 2-O-sulphation within HS, particularly of iduronate residues, is essential for HS...
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