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Sequence analysis of integrated hepatitis B virus DNA during HBeAg-seroconversion

6 Aug 2018

Abstract excerpt

Hepatitis B virus (HBV) integration into the host cell genome occurs early on in infection and reportedly induces pro-oncogenic changes in hepatocytes that drive HCC initiation. However, it remains unclear when these changes occur during hepatocarcinogenesis. Extensive expansion of hepatocyte clones with a selective advantage was shown to occur prior to cancer formation during the HBeAg-seroconversion phase of...

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PMID: 30087321
DOI: 10.1038/s41426-018-0145-7

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