Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatitis B Virus DNA Integration Drives Carcinogenesis and Provides a New Biomarker for HBV-related HCC

1 Jan 2023

Abstract excerpt

Hepatitis B virus (HBV) DNA integration is an incidental event in the virus replication cycle and occurs in less than 1% of infected hepatocytes during viral infection. However, HBV DNA is present in the genome of approximately 90% of HBV-related HCCs and is the most common somatic mutation. Whole genome sequencing of liver tissues from chronic hepatitis B patients showed integration occurring at random positions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to Hepatitis B Virus Studies
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36690297
DOI: 10.1016/j.jcmgh.2023.01.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatitis B Virus DNA Integration Drives Carcinogenesis and Provides a New Biomarker for HBV-related HCCPMID 36690297Read ↗

HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion SiteSemantic proximity Read ↗

Hepatitis B virus DNA integration as a novel biomarker of hepatitis B virus-mediated pathogenetic properties and a barrier to the current strategies for hepatitis B virus cureSemantic proximity Read ↗

Somatic Mutations, Viral Integration and Epigenetic Modification in the Evolution of Hepatitis B Virus-Induced Hepatocellular CarcinomaSemantic proximity Read ↗

Insights into Hepatitis B Virus DNA Integration-55 Years after Virus DiscoverySemantic proximity Read ↗

HBV DNA Integration into Telomerase or MLL4 Genes and TERT Promoter Point Mutation as Three Independent Signatures in Subgrouping HBV-Related HCC with Distinct FeaturesSemantic proximity Read ↗

Cellular Genomic Sites of Hepatitis B Virus DNA IntegrationSemantic proximity Read ↗

Role of hepatitis B virus DNA integration in human hepatocarcinogenesis.Semantic proximity Read ↗

HBV DNA integration and somatic mutations in HCC patients with HBV-HCV dual infection reveals profiles intermediate between HBV- and HCV-related HCC.Semantic proximity Read ↗

HBV-Integration Studies in the Clinic: Role in the Natural History of InfectionSemantic proximity Read ↗

Distinct Patterns of HBV Integration and TERT Alterations between in Tumor and Non-Tumor Tissue in Patients with Hepatocellular Carcinoma.Semantic proximity Read ↗

Genomic and oncogenic preference of HBV integration in hepatocellular carcinomaSemantic proximity Read ↗

Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.