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Article

Cellular Genomic Sites of Hepatitis B Virus DNA Integration

20 Jul 2018

Abstract excerpt

Infection with the Hepatitis B Virus (HBV) is one of the strongest risk-factors for liver cancer (hepatocellular carcinoma, HCC). One of the reported drivers of HCC is the integration of HBV DNA into the host cell genome, which may induce pro-carcinogenic pathways. These reported pathways include: induction of chromosomal instability; generation of insertional mutagenesis in key cancer-associated genes;...

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PMID: 30037029
DOI: 10.3390/genes9070365

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