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Article

Salvage of the 5-deoxyribose byproduct of radical SAM enzymes.

Nature communications - 6 Aug 2018

Beaudoin Guillaume A W, Li Qiang, Folz Jacob, Fiehn Oliver, Goodsell Justin L, Angerhofer Alexander, Bruner Steven D, Hanson Andrew D

Abstract excerpt

5-Deoxyribose is formed from 5'-deoxyadenosine, a toxic byproduct of radical S-adenosylmethionine (SAM) enzymes. The degradative fate of 5-deoxyribose is unknown. Here, we define a salvage pathway for 5-deoxyribose in bacteria, consisting of phosphorylation, isomerization, and aldol cleavage steps. Analysis of bacterial genomes uncovers widespread, unassigned three-gene clusters specifying a putative kinase,...

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Identifiers

PMID: 30082730
DOI: 10.1038/s41467-018-05589-4
PMCID: PMC6079011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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