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Article

Radical SAM enzymes in the biosynthesis of sugar-containing natural products.

Biochimica et biophysica acta - 1 Nov 2012

Ruszczycky Mark W, Ogasawara Yasushi, Liu Hung-Wen

Abstract excerpt

Carbohydrates play a key role in the biological activity of numerous natural products. In many instances their biosynthesis requires radical mediated rearrangements, some of which are catalyzed by radical SAM enzymes. BtrN is one such enzyme responsible for the dehydrogenation of a secondary alcohol in the biosynthesis of 2-deoxystreptamine. DesII is another example that catalyzes a deamination reaction necessary...

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Identifiers

PMID: 22172915
DOI: 10.1016/j.bbapap.2011.11.006
PMCID: PMC3438383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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