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Article

Mechanism-Based Strategies for Structural Characterization of Radical SAM Reaction Intermediates.

Methods in enzymology - 1 Jan 2017

Davis Katherine M, Boal Amie K

Abstract excerpt

X-ray crystallographic characterization of enzymes at different stages in their reaction cycles can provide unique insight into the reaction pathway, the number and type of intermediates formed, and their structural context. The known mechanistic diversity in the radical S-adenosylmethionine (SAM) superfamily of enzymes makes it an appealing target for such studies as more than 100,000 sequences have been...

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PMID: 28882206
DOI: 10.1016/bs.mie.2017.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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