The Radical SAM Enzyme BlsE Can Operate as a Dehydratase, Dehydrogenase, or Epimerase upon Mutation of a Single Active Site Serine Residue.

Abstract excerpt

Radical S-adenosylmethionine (SAM) enzymes are versatile biocatalysts catalyzing a broad range of radical-mediated transformations. While the native enzymes typically catalyze reactions that yield specific products of biosynthetic relevance, structural variation of the active site or the substrate itself can perturb this tightly controlled process, leading to changes in the reaction outcome. BlsE is a twitch...

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