Article
Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes.
Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2018
Petrova Boryana, Liu Keke, Tian Caiping, Kitaoka Maiko, Freinkman Elizaveta, Yang Jing, Orr-Weaver Terry L
Abstract excerpt
The metabolic and redox state changes during the transition from an arrested oocyte to a totipotent embryo remain uncharacterized. Here, we applied state-of-the-art, integrated methodologies to dissect these changes in Drosophila We demonstrate that early embryos have a more oxidized state than mature oocytes. We identified specific alterations in reactive cysteines at a proteome-wide scale as a result of this...
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