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Article

The oocyte-enriched metabolite serotonin alleviates cellular senescence and aging phenotypes in the mouse.

The EMBO journal - 1 Jul 2026

Xu Yuyan, Zhang Ling, Liao Xufeng, Fan Yuhang, Shao Rouyi, Wu Mengchen, Zhang Li, Zhang Min, Wang Gang, Zhang Hailing, Li Enze, Wu Qixin, Zhao Jing, Zhang Jia, Wang Wenjie, Cai Limeng, Zhong Jinjie, Hu Lidan, Wang Jingjing, Mao Jianhua, Yang Bing, Zhang Jin

Abstract excerpt

Whether metabolites enriched at early developmental stages affect cellular and organismal aging remains unclear. In this study, we comprehensively profiled the metabolic landscape of mouse oocytes in comparison to cleavage-stage embryos. Our analysis revealed that oocytes display accumulation of reductive metabolites that diminish following fertilization. Notably, we identified serotonin (5-hydroxytryptamine,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42303757
DOI: 10.1038/s44318-026-00832-x
PMCID: PMC13373241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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