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Article

Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers.

BMC cancer - 6 Aug 2018

Kordowski Felix, Kolarova Julia, Schafmayer Clemens, Buch Stephan, Goldmann Torsten, Marwitz Sebastian, Kugler Christian, Scheufele Swetlana, Gassling Volker, Németh Christopher G, Brosch Mario, Hampe Jochen, Lucius Ralph, Röder Christian, Kalthoff Holger, Siebert Reiner, Ammerpohl Ole, Reiss Karina

Abstract excerpt

BACKGROUND: ADAMs (a disintegrin and metalloproteinase) have long been associated with tumor progression. Recent findings indicate that members of the closely related ADAMTS (ADAMs with thrombospondin motifs) family are also critically involved in carcinogenesis. Gene silencing through DNA methylation at CpG loci around e.g. transcription start or enhancer sites is a major mechanism in cancer development. Here,...

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Source

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Identifiers

PMID: 30081852
DOI: 10.1186/s12885-018-4701-2
PMCID: PMC6080380

Genes

ADAMTS16
ADAMTS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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