Article
Methylation of MGMT and ADAMTS14 in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans.
Oncotarget - 20 Feb 2015
Alonso Sergio, Dai Yuichi, Yamashita Kentaro, Horiuchi Shina, Dai Tomoko, Matsunaga Akihiro, Sánchez-Muñoz Rosa, Bilbao-Sieyro Cristina, Díaz-Chico Juan Carlos, Chernov Andrei V, Strongin Alex Y, Perucho Manuel
Abstract excerpt
Somatic hypermethylation of the O6-methylguanine-DNA methyltransferase gene (MGMT) was previously associated with G > A transition mutations in KRAS and TP53 in colorectal cancer (CRC). We tested the association of MGMT methylation with G > A mutations in KRAS and TP53 in 261 CRCs. Sixteen cases, with and without MGMT hypermethylation, were further analyzed by exome sequencing. No significant association of MGMT...
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