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Article

The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis

28 Nov 2010

Abstract excerpt

The human ADAMTS (a disintegrin and metalloproteinase with thrombospondin-like motifs) family of 19 secreted, multidomain proteolytic enzymes is involved in a wide range of biological processes including ECM assembly and degradation, hemostasis, organogenesis and the regulation of angiogenesis. Defects in certain family members give rise to inherited human genetic diseases, while aberrant expression of other...

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PMID: 21196270
DOI: 10.2741/3827

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