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Article

Genetic Inactivation of ADAMTS15 Metalloprotease in Human Colorectal Cancer

19 May 2009

Abstract excerpt

Matrix metalloproteinases have been traditionally linked to cancer dissemination through their ability to degrade most extracellular matrix components, thus facilitating invasion and metastasis of tumor cells. However, recent functional studies have revealed that some metalloproteases, including several members of the ADAMTS family, also exhibit tumor suppressor properties. In particular, ADAMTS1, ADAMTS9, and...

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PMID: 19458070
DOI: 10.1158/0008-5472.can-08-4155

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