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Article

Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers

1 Dec 2008

Abstract excerpt

BACKGROUND: Multiple epigenetic and genetic changes have been reported in colorectal tumors, but few of these have clinical impact. This study aims to pinpoint epigenetic markers that can discriminate between non-malignant and malignant tissue from the large bowel, i.e. markers with diagnostic potential. The methylation status of eleven genes (ADAMTS1, CDKN2A, CRABP1, HOXA9, MAL, MGMT, MLH1, NR3C1, PTEN, RUNX3,...

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Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19117505
DOI: 10.1186/1476-4598-7-94

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