Article

Ribosome abundance, not paralogue composition, is essential for germline development

2024-11-14

Abstract excerpt

<h4>Summary</h4> Ribosomes catalyse all protein synthesis, and mutations altering their levels and function underlie many developmental diseases and cancer. Historically considered to be invariant machines, ribosomes differ in composition between tissues and developmental stages, incorporating a diversity of ribosomal proteins (RP) encoded by duplicated paralogous genes. Here, we use Drosophila to systematically...

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Literature Corpus work: af472790-34f2-506e-998e-affe91ffad7b
DOI: 10.1101/2024.11.14.623487

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