Article
The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation.
Nucleic acids research - 19 Sept 2017
Gómez-Herreros Fernando, Margaritis Thanasis, Rodríguez-Galán Olga, Pelechano Vicent, Begley Victoria, Millán-Zambrano Gonzalo, Morillo-Huesca Macarena, Muñoz-Centeno Mari Cruz, Pérez-Ortín José E, de la Cruz Jesús, Holstege Frank C P, Chávez Sebastián
Abstract excerpt
Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA polymerases. Transcription elongation involves dynamic interactions between RNA polymerases and chromatin. We performed a synthetic lethal screening in Saccharomyces cerevisiae with a conditional allele of SPT6, which encodes one of the factors that facilitates this process. Some of these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.