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Article

Drosophila ribosomal protein mutants control tissue growth non-autonomously via effects on the prothoracic gland and ecdysone.

PLoS genetics - 1 Dec 2011

Lin Jane I, Mitchell Naomi C, Kalcina Marina, Tchoubrieva Elly, Stewart Mary J, Marygold Steven J, Walker Cherryl D, Thomas George, Leevers Sally J, Pearson Richard B, Quinn Leonie M, Hannan Ross D

Abstract excerpt

The ribosome is critical for all aspects of cell growth due to its essential role in protein synthesis. Paradoxically, many Ribosomal proteins (Rps) act as tumour suppressors in Drosophila and vertebrates. To examine how reductions in Rps could lead to tissue overgrowth, we took advantage of the observation that an RpS6 mutant dominantly suppresses the small rough eye phenotype in a cyclin E hypomorphic mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22194697
DOI: 10.1371/journal.pgen.1002408
PMCID: PMC3240600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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