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Human pluripotent stem cell-derived intestinal organoids for pharmacokinetic studies

4 Apr 2025

Abstract excerpt

The human small intestine is essential for orally administered drugs' absorption, metabolism, and excretion. Human induced pluripotent stem cell (hiPSC)-derived intestinal epithelial cells (IECs) offer a useful model for evaluating drug candidate compounds. We previously reported a protocol to generate matured enterocyte-like cells that exhibit P-gp-mediated efflux and cytochrome P450 3A (CYP3A)-mediated...

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PMID: 40199084
DOI: 10.1016/j.ejcb.2025.151489

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