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Article

CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window.

Nature - 1 Aug 2018

Halperin Shakked O, Tou Connor J, Wong Eric B, Modavi Cyrus, Schaffer David V, Dueber John E

Abstract excerpt

The capacity to diversify genetic codes advances our ability to understand and engineer biological systems1,2. A method for continuously diversifying user-defined regions of a genome would enable forward genetic approaches in systems that are not amenable to efficient homology-directed oligonucleotide integration. It would also facilitate the rapid evolution of biotechnologically useful phenotypes through...

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PMID: 30069054
DOI: 10.1038/s41586-018-0384-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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