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Article

A Cas3-base editing tool for targetable in vivo mutagenesis.

Nature communications - 9 Jun 2023

Zimmermann Anna, Prieto-Vivas Julian E, Cautereels Charlotte, Gorkovskiy Anton, Steensels Jan, Van de Peer Yves, Verstrepen Kevin J

Abstract excerpt

The generation of genetic diversity via mutagenesis is routinely used for protein engineering and pathway optimization. Current technologies for random mutagenesis often target either the whole genome or relatively narrow windows. To bridge this gap, we developed CoMuTER (Confined Mutagenesis using a Type I-E CRISPR-Cas system), a tool that allows inducible and targetable, in vivo mutagenesis of genomic loci of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37296137
DOI: 10.1038/s41467-023-39087-z
PMCID: PMC10256805

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