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Article

Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration.

The Journal of biological chemistry - 15 Jun 2012

Tiaden André N, Klawitter Marina, Lux Vanda, Mirsaidi Ali, Bahrenberg Gregor, Glanz Stephan, Quero Lilian, Liebscher Thomas, Wuertz Karin, Ehrmann Michael, Richards Peter J

Abstract excerpt

Human HTRA1 is a highly conserved secreted serine protease that degrades numerous extracellular matrix proteins. We have previously identified HTRA1 as being up-regulated in osteoarthritic patients and as having the potential to regulate matrix metalloproteinase (MMP) expression in synovial fibroblasts through the generation of fibronectin fragments. In the present report, we have extended these studies and...

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Source

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Identifiers

PMID: 22556410
DOI: 10.1074/jbc.M112.341032
PMCID: PMC3375554

Genes

HTRA1
IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration.PMID 22556410Read ↗

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Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome.Semantic proximity Read ↗

A novel heterozygous HTRA1 mutation is associated with autosomal dominant hereditary cerebral small vessel disease.Semantic proximity Read ↗

HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8.Semantic proximity Read ↗

HTRA1 expression profile and activity on TGF-β signaling in HTRA1 mutation carriers.Semantic proximity Read ↗

Overexpression of HTRA1 leads to down-regulation of fibronectin and functional changes in RF/6A cells and HUVECs.Semantic proximity Read ↗

Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2Semantic proximity Read ↗

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